「股骨头坏死」素有「不死癌症」之称，其主要病理为股骨头遭受破坏而引起的股骨头骨质缺血，多称为股骨头缺血性坏死或股骨头无菌性坏死。严重危害著患者的身心健康，在股骨头坏死发病早期症状不太明显，一般情况下对患者影响不大，因此时常给患者造成错觉，容易错失治疗时机，一旦病情没有得到有效地控制，就会造成大部分股骨头消失，从而导致患者终身丧失劳动能力，无法进行正常生活。1

    根据在Mol Med Rep.发表的文献指出，使用脐带间叶干细胞可治疗股骨头坏死。该篇文献针对9名股骨头坏死的病患，其分期介于Ⅱ‑Ⅲa的患者进行动脉注射脐带间叶干细胞治疗，并追踪3年。结果发现，治疗12和24个月后，患者股骨头坏死体积明显减少，没有其他不良反应。数据指出，通过动脉注射的脐带间叶干细胞，移动到股骨头坏死区域，分化为「成骨细胞」，进而改善股骨头坏死。研究显示，使用脐带间叶干细胞治疗股骨头坏死，是可行且安全的方法。2

注：

股骨(femur)是人体最长的骨头，又称为大腿骨。它的最上端形成一个圆球，連成髋关节的一部份。髋关节是由髋臼及股骨头所组成3，其组成如下图所示4：

髋关节组成.jpg

参考文献：

1. https://kknews.cc/zh-tw/health/65k693.html

2. https://www.ncbi.nlm.nih.gov/pubmed/27634376

    Mol Med Rep. 2016 Nov;14(5):4209-4215.

3. https://www.ntuh.gov.tw/orth/education/DocLib/%E8%82%A1%E9%AA%A8%E9%A0%AD%E5%A3%9E%E6%AD%BB.aspx

4. https://pic.pimg.tw/prpp3562350/1467117372-3784992836_n.jpg?v=1467117380

 

Efficacy of umbilical cord-derived mesenchymal stem cell-based therapy for osteonecrosis of the femoral head: A three-year follow-up study.

Abstract

This is a retrospective analysis of the clinical effects of transplant of mesenchymal stem cells (MSCs) derived from human umbilical cord-derived MSCs (hUC‑MSCs) for the treatment of osteonecrosis of the femoral head (ONFH). The biological characteristics of hUC-MSCs were assessed using flow cytometry. Nine eligible patients were enrolled in the study as they adhered to the Association Research Circulation Osseous (ARCO) classification of stage Ⅱ‑Ⅲa, and hUC‑MSCs were grafted by intra‑arterial infusion. Organize effective perfusion was assessed using the oxygen delivery index (ODI). The results showed that the ODI was increased at three days post‑operation. The MRI results revealed that at 12 and 24 months after treatment, the necrotic volume of the femoral heads was significantly reduced. No obvious abnormalities were observed. Taken together, these data indicate that intra‑arterially infused hUC‑MSCs migrate into the necrotic field of femoral heads and differentiate into osteoblasts, thus improving the necrosis of femoral heads. This finding suggested that intra‑arterial infusion of hUC‑MSCs MSCs is a feasible and relatively safe method for the treatment of femoral head necrosis.

Mol Med Rep. 2016 Nov;14(5):4209-4215.

 

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