很榮幸，我們邀請到了這兩位老師，他們熱情地爲我們分享他們在STEM項目的教學經驗和未來的培養計劃。

Dr.Edward Gasanoff, a chemistry teacher at the Chaoyang KaiWen Academy (CKWA), andMr. Feng Li, a curriculum researcher at the KaiWen Education Group, havelaunched an advanced STEM program for the secondary school students in the CKWA in the Fall semester of 2018. The aim ofthe STEM program was to advance understanding of the CKWA students in physicsand chemistry of chemical bonding, macromolecular spatial structure, intermolecular interactions and structure-function relationships ofmacromolecules – the most difficult concepts of the IBDP science courses – andto involve the CKWA students in the collaborative scientific research studies withthe two US universities, the Nevada University Reno Medical School and thePittsburg University.In the second weekof March 2019, a collaboration of the STEM program of CKWA with the two USuniversities has produced a research article which was published in Toxins – ahigh impact peer-reviewed scientific journal in area of biochemical andbiomedical molecular mechanisms of natural toxins. Dr. Edward Gasanoff and Mr. Feng Li have beeninterviewed by the marketing department of the KaiWen Education Group in the regardof this publication.

重要意義

記者

兩週前，朝陽凱文學校與兩所美國大學合作，在一家在其專業領域內有很高影響力的科學期刊上發佈了論文。這對於CKWA這一所K12學校來說具有非常重要的學術意義。 鑑於本文的作者之一是朝陽凱文的中學生，這使得本次論文的發表成爲中學教育領域的極具價值的事件。 您同意我的想法嗎？ 如果是的話，我們想請您談談這篇文章的發表對於我們CKWA有怎樣的意義？

Twoweeks ago, the Chaoyang KaiWen Academy (CKWA) – one of the schools of theKaiWen Education Group – has published a scientific research article incollaboration with the two US universities in a highly influential academicjournal. This collaboration hassignificant academic meaning for a K12 school like CKWA. Given that one of theauthors of this article is complete by a CKWA secondary school student, thismakes this publication became a huge news in the field of secondaryeducation. Would you agree with me? If yes, please tell us what this publication haspublished is meaning for the CKWA?

Edward Gasanoff：是的，我同意你的觀點。雖然朝陽凱文學校不是一所大學，但它可能是第一所能讓其中學生參與美國大學一線生物化學研究的學校。我們朝陽凱文學校的學生爲這項研究作出了不少貢獻，因此可以在發表的科學論文上署名，論文發表的期刊在其領域內有很高的影響力。

EdwardGasanoff: Yes, I do agree with you. As you know theCKWA is not a tertiary education,however as far as Iknow the CKWA is possibly the first secondary school in China which hasinvolved its secondary school students in the front line biomedical chemistryresearch together with US universities. The students of CKWA made an amplecontribution to this research, therefore one of the students allowed to co-authoredthis research article in a high impact peer-reviewed scientific journal in areaof biochemical molecular toxicology.

李峯：本次論文的發表，表明我們朝陽凱文學校有着非常優秀和努力的學生，也有一羣非常專業，有着很高學術造詣的教師。我們教師的學術水準可以與美國大學的專業研究人員合作，指導學生參與真實的科研活動。我們學校有着對科學充滿熱情的學生、專業的教師以及與美國大學實驗室的合作機會。這些都表明有深度的研究不是僅僅只有在大學才能開展，朝陽凱文學校也同樣具備培養學生科學研究能力的條件和學術水平，這也是我們學校辦學特色之一。

FengLi: Thispublication not only showing that the student of CKWA are outstanding andhardworking, but also showing CKWA has the professional and highly skilledacademic staff, which capable of guiding the students' research activities in areal scientific research environment in collaboration with the researchers fromthe US universities. The CKWA havescience motivated students, a highly skilled science academic staff, plus thechance of in collaboration with the front-line US research laboratories – allthese represent the research activity is not only for tertiary institutions,the CKWA also have the ability to educate student with the same scientific andacademic level , which is also an unique signature feature for the school.

學生參與研究

記者

研究性項目中培養的綜合能力如何使CKWA的學生受益？

Howdoes this blend of skills and capabilities benefit the CKWA students?

Edward Gasanoff：CKWA在中學階段開設劍橋國際課程（CIE），即將在高中開設國際文憑課程（IBDP）。 CIE和IBDP都是高水平和具有挑戰性的課程，IBDP特別強調考察學生的批判性思考能力、分析能力以及獨立研究的能力。例如，Extendedessay就通過寫論文的形式考察學生的研究性學習的能力。這其實非常具有挑戰性，因爲一篇嚴謹的科學論文的寫作不僅需要高水平的學術寫作能力，還需要很強的數據分析、展示、論述和總結能力。因此，在CKWA開展的參與大學科研的STEM項目，對於學生IBDP的學習，也會有很大幫助。

EdwardGasanoff:The CKWA runs the Cambridge International Examinations (CIE) curriculum in itssecondary school and is about to start the International Baccalaureate DiplomaProgramme (IBDP) in its high school. BothCIE and IBDP are exceptionally advanced and challenging educational programsand IBDP is particularly rigorous in its assessment of students’ critical andanalytical thinking skills and independent research skills. This is assessed through the externalevaluation of the students’ research study skills in a form of extended essay,which is a very challenging task particularly in sciences where the extendedessay requires not only a high level of academic writing, but also anexceptional research data presentation, analysis, discussion and conclusion ata level of scientific article. We usethe skills and capabilities we have in the CKWA to run the STEM program inwhich we prepare our students for the IBDP extended essay projects by involvingthe students in the university scientific research projects.

李峯：在我們開展的STEM項目中，我們的學生參與了內華達大學裏諾醫學院藥理學系教授Ruben Dagda博士的實驗室研究項目。 Dagda博士主要研究神經退化的分子機理，其中一個研究方向就是神經細胞線粒體膜的結構變化可能會導致神經退化。 Dagda博士使用了一種眼鏡蛇毒作爲探針來研究線粒體膜的結構和功能。我們的學生通過STEM項目也參與了這項研究，做出了一定的貢獻，我們的論文也最終發表在科學期刊上。在這個過程中，學生的批判性思考能力、分析能力以及獨立研究的能力得到了充分鍛鍊，這對於他未來IBDP的學習也會有很大幫助。

Feng Li:In our STEM program we align the researchactivities of students with the research projects run in the laboratory of Dr.Ruben Dagda, a professor at the Pharmacology Department of the NevadaUniversity Reno Medical School. Dr.Dagda studies molecular mechanisms of neurodegeneration. One of his particular interests relates to thechanges in membrane structure of mitochondria in neural cells which courseneurodegeneration. Dr. Dagda employscobra venom cardiotoxins, which target mitochondria, to probe the structure andfunctions of mitochondrial membranes. Weinvolve our STEM students in the Dr. Dagda research studies, and we make surethat the academic level of the students’ research is high enough that it cancontribute to the scientific merit of the Dr. Dagda’s research so it can bepublished in the peer-reviewed scientific journals. We believe that the STEM students who succeedto publish a scientific article has had developed a high level of critical andanalytical thinking skills and independent research skills to complete anexcellent extended essay by the IBDP criteria.

（圖一：Pymol1CDT pc head 作用位點分析）

記者

您是如何培養STEM項目組的學生參與Dagda博士實驗室的科學研究的？

How do you teach the STEM students so they can participate in the scientificresearch carried out in the Dr. Dagda’s laboratory?

Edward Gasanoff：在參與研究之前，我們首先教授了一些基礎的理論， 我們嘗試爲這個項目專門開發了一個課程。課程包括原子結構和電子排布，離子鍵和共價鍵的化學鍵理論，鮑林的電負性理論，極性和非極性共價鍵理論，分子間的相互作用：離子鍵，極性共價鍵、氫鍵以及範德瓦爾斯力，生物分子三維結構的物理化學分析，以及某些特殊的分子間相互作用。後面的課程我們則專注於生物大分子空間結構的計算機模擬，以及生物分子的對接計算。 Dagda博士是美國內華達州的STEM權威，正在協助複查我們的STEM課程，我們有計劃未來一起把課程發表在美國的“STEM Outreach”期刊上。

EdwardGasanoff:We first start with the theory before we involve our students in the relevantresearch studies. We have developed a curriculum for the first year STEMprogram which we are test running at the moment and will complete it in abouttwo months. The curriculum includesatomic structure with electron configurations, chemical bonds with particularemphasis on ionic and covalent bonds, Pauling’s theory of electronegativitywith emphasis on polar and non-polar covalent bonds, intermolecularinteractions in terms of ionic, polar and hydrogen bonds, and wan der Waalsforces, physics and chemistry of 3-D structure of biomolecules and particulartypes of intermolecular interactions. After that, we have focused on computermodeling of spatial structure and docking of biomacromolecules. Dr. Dagda, who is a STEM authority in thestate of Nevada in the USA, is reviewing our STEM curriculum and we are goingto jointly publish it the “Journal of STEM Outreach” in the USA.

李峯：我們目前正在教我們的STEM學生學習使用Auto Dock Vina程序將毒素蛋白質與磷脂進行對接計算，並分析磷脂分子在蛋白質分子表面上的結合位點以及分子間作用力的類型。我們用計算機靜態計算所獲得的結果與Dagda博士、Gasanoff博士和Shrivastava博士實驗室獲得的實驗結果能比較好的吻合，於是我們就在Toxins上一起合作發表了論文。

Feng Li: Dr. Dagda and Dr. Indira Shrivastava from theUniversity of Pittsburg sent us digital files of several protein cardiotoxinsand phospholipids found in mitochondrial membranes. We are currently teaching our STEM studentsto dock protein cardiotoxins with phospholipids using AutoDock Vina program andanalyze types of intermolecular bonding and the binding sites on the molecularsurface of proteins. The results of ourcomputer modeling studies on one particular cardiotoxin aligned well withexperimental results obtained in laboratories of Dr. Dagda, Dr. Gasanoff andDr. Shrivastava, and we have published an article in Toxins describing ourcollaborative results.

（圖二：Pymol1CDT PC相互作用）

STEM項目

記者

未來您對該項目的授課計劃是什麼呢？

Whatare you going to teach the STEM students next year?

Edward Gasanoff：明年我們將繼續教授我們STEM的學生通過計算機3D建模程序來分析生物大分子。此外，我們將邀請另一位CKWA老師William Xu和我們一起，他將教授我們的學生計算機編程的基礎，以及如何用物理公式描述生物分子的生理行爲。如何用物理公式來描述生物大分子生理行爲是一項艱鉅的任務，這可能只能由該領域的少數科學家才能完成，我們這裏將只教授一些基礎知識，以便於我們的STEM學生未來在大學或者研究生階段深入學習研究這個領域。上述技能在生物分子工程的物理和化學機制研究中非常重要，這是現代科學技術的最新趨勢。

Edward Gasanoff: Next year we willcontinue teaching the STEM students computer modeling programs for analysis ofbiomacromolecules. In addition, we willinvolve William Xu, another CKWA teacher, who will teach STEM students computerprogramming aligned with physiological behavior of biomolecules in terms ofphysical formulas. Describingphysiological behavior of biomacromolecules in terms of physical formulas is adifficult task which is done by a very few scientists in the field, and we willtouch only bases here so the STEM students get the basic skills in this fieldwhich they will further develop in the university and after universitystudies. These skills are very importantin the physics and chemistry of biomolecular engineering which is the newesttrend in modern science and technology.

李峯：在我們開展的項目中，我們做了從10-12年級三年的學習計劃。10年級我們將我們的授課內容作爲IGCSE科學課程的補充。11年級是IBDP課程的第一年，我們將補充學習計算機編程以及生物分子結構的物理特徵和生理學意義。12年級是IBDP科學課程的第二年，我們的課程除了補充DP科學的學習，研究項目還可以作爲Extended Essay的研究主題。我們希望未來深度的發展朝陽凱文學校的STEM課程，我們的項目也得到了內華達大學裏諾醫學院藥理學系Ruben Dagda博士的熱情支持，他將會爲我們提供更多的合作研究、學生指導和交流學習上的機會。如果我們的項目開展順利的話，未來我們還會考慮邀請莫斯科大學的博士後教授我們的學生高級計算機編程。我們希望有更多的熱愛科學，並且希望在科學領域發展的優秀學生加入我們朝陽凱文學校的STEM項目。

Feng Li: In our project, we preparedour three years STEM study plan forGrades 10, 11 and 12 students. In theGrade 10 the STEM curriculum that we have already covered this academic yearwill supplement IGCSE curriculum. In theGrade 11 we will supplement the first year IBDP sciences curricula with thecomputer programming and physics and physiology of biomolecular structure. In the Grade 12 we will enrich the secondyear IBDP sciences curricula with the research studies related to the extendedessay projects. The STEM program at theCKWA will be dynamically developing and will be supported by Dr. Ruben Dagda ofthe Pharmacology Department of the Nevada University Reno Medical School interms of scientific research collaboration, students mentoring and exchange. Shouldthe STEM developing successfully, in the second three-years cycle of STEM we mayconsider recruiting a post-doc from the Moscow State University to teach STEM studentsadvanced computer programming. We hope that more outstanding students whopassionate about science and hoping to develop themselves in the field ofscience will join CKWA STEM program.

記者

我們的STEM項目會在學生大學專業選擇和未來的工作選擇中提供幫助嗎？

Willthe STEM program help the students with choosing the field of studies inuniversity and with the job quests after the students graduate a university?

Edward Gasanoff：生物化學工程和人工酶的領域在未來有着廣闊的發展前景的科學前沿，我們目前開展的項目希望爲有志於在這個領域發展的學生打好基礎。對整個人類來說，我們未來面臨着人口指數增長所帶來的巨大人口壓力，這個領域的研究進展有望幫我們解決這個重大問題，目前美國的頂尖大學和俄羅斯的莫斯科大學都在致力於這個領域的研究。我們開展的STEM項目希望培養有有興趣的優秀學生進入世界頂尖大學以從事這個領域的研究。

Edward Gasanoff: The CKWA STEM aims at fostering the skillsneeded in biochemical engineering and artificial enzymes which are the newestdirections in the cutting-edge science focused at developing the technologiesof the future. The questions with thedevelopment of these technologies, which are to mitigate the looming challengesof exponentially growing human population, are being currently addressed only bythe top universities in the USA and the Moscow State University in Russia. We prepare our advanced STEM students toenter the top world universities to pursue the careers in the field ofbiochemical engineering of biomolecules and artificial enzymes.

李峯：生物化學工程和人工酶這個領域在解決能源危機，食物短缺以及環保產品的生產上有着非常大的應用價值。其中一些技術的開發，例如如何應對氣候變化，目前梅琳達和比爾蓋茨基金會也在資助這方面的研究。未來對這個領域的人才將會有很大的需求。

Feng Li: In our current STEM program of CKWA ,we aim at developing the skills which will steer our students’interest towards biochemical engineering and artificial enzymes which willdevelop new technologies to solve energy problems, shortage of food,environmentally friendly goods production and etc. Development of some of these technologies,such as dealing with the climate change for example, are currently funded bythe Melinda and Bill Gates Foundation. The skills in this kind of science and technology are in a big demandnow and will be in even greater demand in foreseeable future.

記者

STEM項目是如何與CKWA相輔相成的？

How will the STEM program help in advancing thereputation of the CKWA?

Edward Gasanoff：我們的STEM項目致力於培養對科學有着極大興趣並且希望在科學領域發展的優秀學生。這對學校良好學習風氣的建立會有着非常積極的作用。在我們的項目中，學生有機會參與一線科學研究領域，也有機會署名發表研究論文，這顯然有助於我們的畢業生進入世界頂尖大學，也有助於建立我們凱文學校在學術上的口碑。

Edward Gasanoff:Our STEM program aimed atattracting the science motivated and academically advanced students to theCKWA. It is a well-known fact that anynew academically advanced student always adds a positive dynamics to theefficient learning in a class. The STEM isdesigned to promote the students scientific research to be published in thehigh impact peer reviewed journals which will obviously help the advanced CKWAstudents to enter the top world universities. Altogether the STEM will advance the reputation of the CKWA as a schoolof the high academic excellence.

評價

記者

聽完兩位老師的介紹，我們受益匪淺，並對那位深入參與了研究項目的九年級同學Zhengyao Chen產生了濃厚的興趣，請兩位老師簡單評價一下他吧？

Zhengyao Chen is a studentfrom the CKWA STEM program who has co-authored the article published in Toxins. Could you give us your comment on Zhengyao Chen?

Edward Gasanoff：ZhengyaoChen是一個非常有才能的學生，他很好學並且也有很強的學習能力。他在這個年紀，就已經可以理解很多這個領域內相當於大學本科水平的知識。目前我們正在教他學習更多的科學概念，以及一些真實的科學實驗室需要的研究技能。我們期待他未來有機會進入世界頂尖大學併成爲某個科技領域的專家。

Edward Gasanoff: Zhengyao Chen is a very exceptional student. He is very studious,and he has development excellent learning skills. At his age he can alreadyunderstand material that is taught at the undergraduate university level. At the moment we are working with him on the science concepts and methods usedin the real scientific laboratory environment. He has a high chance ofentering to one of the top world universities and later become one of thehigh-level experts in the field of science and technology.

李峯：從去年開始，我在凱文的STEM項目中和Edward教授一起教ZhengyaoChen分子生物工程的知識，Zhengyao Chen是個好奇心很強，悟性很高，並且主動性很強的優秀學生，他能很快理解生物化學上有深度的知識，掌握計算機模擬和數據分析的一些技巧。讓我更看重的，他也是個很懂事、很正直的孩子。我非常希望Zhengyao Chen未來能夠繼續在這個方向上深入學習發展，甚至有機會做出一些重要的研究突破和進展。

FengLi: Sincelast year, I have been teaching Zhengyao Chen together with Professor Edward inour STEM project. Zhengyao Chen is an excellent, motivated student with strongcuriosity. Zhengyao Chen was able to quickly understand the key concepts inBiochemistry and pick up the essential skills of computer simulation and dataanalysis. What I value more is that he is also a mature and upright person. I hopeZhengyao Chen will focus on this field, gain deeper understanding and maybeeventually have the chance to make someimportant breakthroughs in the research of this field.

我們非常感謝兩位老師對本次採訪的大力支持，他們的回答解決了我們大部分的困惑，併爲朝陽凱文學校未來在STEM項目上的發展提供了極爲建設性的幫助。據幾位神祕的STEM項目組成員介紹，朝陽凱文正在朝着更遠的科學課程邁進，他們認爲在不久的將來，STEM課程將會在培養中國新型人才上起到舉足輕重的作用，在未來，更爲複雜的社會網絡與更加龐大的科技世界需要大量的跨學科人才，我們將竭盡全力承擔起這樣的教育責任。

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